ecancermedicalscience

Special Issue

Gut microbiota, chemotherapy and the host: the influence of the gut microbiota on cancer treatment

5 Sep 2018
Anna Louise Pouncey, Alasdair James Scott, James Leslie Alexander, Julian Marchesi, James Kinross

The gut microbiota exists in a dynamic balance between symbiosis and pathogenesis and can influence almost any aspect of host physiology. Growing evidence suggests that the gut microbiota not only plays a key role in carcinogenesis but also influences the efficacy and toxicity of anticancer therapy. The microbiota modulates the host response to chemotherapy via numerous mechanisms, including immunomodulation, xenometabolism and alteration of community structure. Furthermore, exploitation of the microbiota offers opportunities for the personalisation of chemotherapeutic regimens and the development of novel therapies. In this article, we explore the host-chemotherapeutic microbiota axis, from basic science to clinical research, and describe how it may change the face of cancer treatment.

Related Articles

Anass Baladi, Hassan Abdelilah Tafenzi, Fatim-Zahra Megzar, Ibrahima Kalil Cisse, Othmane Zouiten, Leila Afani, Ismail Essaadi, Mohammed El Fadli, Rhizlane Belbaraka
Mohamed Osama Alorabi, Mohamed El-Bassiouny, Dalia Abd El Ghany El Khodary, Mai Mohamed Ali Ezz El Din, Alaa Mohamed Mohamed Ahmed Elsayed, Christine Reda
Priti Singh, Chaithanya Leon, Simran Kaur, Atul Batra, Prashant Tayade, Muthukrishnan Suriya Prakash, Ratna Sharma