High healthcare costs are a major obstacle to treatment and recovery, particularly in low- and middle-income countries. Financial navigation programs (FNPs) are designed to help patients manage these costs by providing support through insurance and providing resources for patients. This study explores the experience of implementing FNPs in Nigeria at two tertiary cancer centers: Lakeshore Cancer Center, Lagos and Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria. Key barriers include low financial literacy, complex regulations and limited financial resources. However, these issues can be overcome with better financial education, simplified regulations and expanded insurance coverage. The study underscores the potential of FNPs to significantly reduce financial strain and improve treatment outcomes for cancer patients in resource-limited settings. Recommendations for the adoption and implementation of an FNP in Nigeria are included in this manuscript.