The pharmacovigilance system oversees medicine safety in Zambia under the ZA Medicines Regulatory Authority, requiring marketing authorisation holders to establish safety monitoring systems.

Healthcare workers are trained and equipped with reporting tools. While there are no specific requirements for cancer medicines, there is a push for better engagement and training in pharmacovigilance. The system focusses on serious adverse drug reactions, especially for new drugs, and utilises both paper and electronic reporting tools.