Supporting oncology professionals through education
The content on this site is intended for healthcare professionals only
The content on this site is intended for healthcare professionals only
High-risk patients with TP53-mutated acute myeloid leukaemia (AML) have limited treatment options and very poor prognoses.
Magrolimab is a monoclonal antibody designed to block CD47 — an immune macrophage checkpoint molecule that signals “don’t eat me,” thereby allowing leukaemia cell destruction.
Combining magrolimab with the hypomethylating agent azacitidine (AZA) helped eliminate tumour cells by increasing the number of “eat me” signals in preclinical studies.
In a Phase Ib trial presented by Naval Daver, M.D., researchers evaluated the safety, efficacy and tolerability of this combination in 72 patients with newly diagnosed high-risk TP53-mutated AML. The objective response rate (ORR) was 48.6% and the complete response rate was 33.3%.
Median time to ORR was 2.2 months. Median CR duration was 7.7 months and median overall survival was 10.8 months.
Common side effects included constipation, diarrhoea, febrile neutropenia, nausea and fatigue.
The findings suggest this combination has a favourable safety profile and encouraging early results. A Phase III trial currently is underway to compare this treatment to the current standard of care therapies in newly diagnosed TP53 AML.
The World Cancer Declaration recognises that to make major reductions in premature deaths, innovative education and training opportunities for healthcare workers in all disciplines of cancer control need to improve significantly.
ecancer plays a critical part in improving access to education for medical professionals.
Every day we help doctors, nurses, patients and their advocates to further their knowledge and improve the quality of care. Please make a donation to support our ongoing work.
Thank you for your support.