A study published in the Journal of Caffeine and Adenosine Research has shown that reduced adenosine kinase expression (ADK) in the liver can make it more susceptible to carcinogenic damage and the development of liver cancer.

Combined results from the study of human liver cancer samples and mice with reduced levels of ADK expression support these findings. 

The researchers showed that 64 percent of patients with liver cancer had lower ADK expression.

ADK is highly expressed in the liver, where it regulates adenosine levels and is important in controlling hepatic metabolism.

The researchers used transgenic technology to generate mice with reduced ADK expression and then exposed them to a carcinogen to study the effects on the animals' body weight and survival.

"These results might represent a very significant advance in the field. Further studies should confirm if adenosine kinase represents a new biomarker or a pharmacological target in liver cancer," says Editor-in-Chief of Journal of Caffeine and Adenosine Research Sergi Ferré, MD, PhD.

Source: Mary Ann Liebert Inc/Genetic Engineering News