A new study has found that tamoxifen, an anti-oestrogen breast cancer medication, may reduce an individual's risk of death from lung cancer. Published early online in Cancer, a peer-reviewed journal of the American Cancer Society, the study supports the hypothesis that there is a hormonal influence on lung cancer and that oestrogen levels play a role in lung cancer patients' prognosis.

Previous research suggests that menopausal hormone therapy increases women's risk of dying from lung cancer. If this is true, the use of anti-oestrogens should have the opposite effect. Elisabetta Rapiti, MD, of the Geneva Cancer Registry led a study that compared lung cancer incidence and mortality among breast cancer patients who were and were not treated with anti-oestrogen therapy. The study included all 6,655 women diagnosed with breast cancer between 1980 and 2003 and registered at the Geneva Cancer Registry. Among these women, 46 percent (3,066) received anti-oestrogens. All women were followed for occurrence and death from lung cancer until December 2007.

The investigators found that 40 women in the study developed lung cancer. Incidences of lung cancer was not significantly different between breast cancer patients who were and were not treated with anti-oestrogens compared with the general population; however, fewer women taking anti-oestrogens died from lung cancer than expected. Specifically, there were 87 percent fewer cases of death due to lung cancer in the anti-oestrogen group than in the general population.

"Our results support the hypothesis that there is a hormonal influence on lung cancer which has been suggested by findings such as the presence of oestrogen and progesterone receptors in a substantial proportion of lung cancers," said Dr. Rapiti. "If prospective studies confirm our results and find that anti-oestrogen agents improve lung cancer outcomes, this could have substantial implications for clinical practice," she added.


Source: Cancer

Article:“Lung cancer mortality risk among breast cancer patients treated with anti-estrogens.” Christine Bouchardy, Simone Benhamou, Robin Schaffar, Helena M. Verkooijen, Gérald Fioretta, Hyma Schubert, Vincent Vinh-Hung, Jean-Charles Soria, Georges Vlastos, Elisabetta Rapiti. CANCER; Published Online: January 24, 2011 (DOI: 10.1002/cncr.25638).