Postmenopausal bleeding is a common symptom among most women with endometrial cancer but most women with postmenopausal bleeding won't be diagnosed with endometrial cancer, findings that raise questions about how to best manage postmenopausal bleeding for the early detection of endometrial cancer.

Endometrial cancer diagnosed early is often curable with surgery but five-year survival rates plummet for late-stage disease.

Accurate estimates of the frequency of postmenopausal bleeding in endometrial cancers and the risk of endometrial cancer in women with postmenopausal bleeding are needed to evaluate whether targeting women with postmenopausal bleeding for early detection is a useful strategy.

Nearly 41,000 from 129 studies (34,000 women with postmenopausal bleeding and more than 6,000 women with endometrial cancer).

Pooled frequency of postmenopausal bleeding in women with endometrial cancer and the risk of endometrial cancer in women with postmenopausal bleeding

This was a systematic review and meta-analysis.

A meta-analysis combines the results of multiple studies identified in a systematic review and quantitatively summarises the overall association between the same exposure and outcomes measured across all studies.

The pooled frequency of postmenopausal bleeding among women with endometrial cancer was 91 percent, while the pooled risk of endometrial cancer among women with postmenopausal bleeding was 9 percent.

Source: JAMA Internal Medicine